Amir Kashefi, M.D. – Interventional Radiology & Functional Medicine

Genesis® Regenerative Protein Array Clinician in Pasadena, CA

Dr. Amir Kashefi, M.D., an interventional radiologist & functional medicine clinician in Pasadena, CA offer regenerative solutions for musculoskeletal, endocrine, and autoimmune health
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Pasadena Health & Surgical Institute – Advanced Solutions for Musculoskeletal, Endocrine, and Autoimmune Health

Amir Kashefi, M.D., is a specialist in interventional radiology and functional medicine at the Pasadena Health & Surgical Institute (PHSI). After graduating from Tehran University, Dr. Kashefi conducted clinical research at Stanford University and UC Davis before training at some of the nation’s most prestigious medical institutions. His clinical practice is defined by a focus on diagnostic precision and a belief that effective medical care identifies and addresses the biological drivers of chronic disease.

Dr. Kashefi’s clinical background includes a residency at UC Davis and Harlem Hospital (affiliated with Columbia University), followed by a two-year fellowship in Interventional Radiology at Massachusetts General Hospital and Harvard Medical School. As a board-certified physician in Interventional Radiology, he utilizes his expertise in minimally invasive procedures and precision imaging to manage complex health challenges. His practice provides specialized support for musculoskeletal injuries, endocrine dysfunction, and chronic GI health issues, alongside protocols for anti-aging and the management of neurological and autoimmune disorders.

Recognizing that conventional medicine often focuses on acute stabilization, Dr. Kashefi addresses the long-term management of chronic illness by evaluating the links between lifestyle, metabolic function, and environmental factors. By combining technical accuracy with personalized wellness strategies, he provides a structured framework for patients to regain functional health and long-term vitality.

Genesis® Regenerative Protein Arrays

In his clinical practice, Dr. Kashefi utilizes the Genesis® Regenerative Protein Array (RPA) as a sophisticated modality for tissue support and repair. RPA represents a “generation beyond” traditional Platelet-Rich Plasma (PRP) or stem cell therapies. It is an acellular product, meaning it contains no whole cells or DNA. This design minimizes the potential for adverse reactions or inflammatory spikes, providing a refined option for patients seeking advanced restorative support.

The primary mechanism of RPA is paracrine signaling—a process where bioactive molecules provide a biochemical “blueprint” that communicates with the patient’s own cells to coordinate a healing response.

Each array contains a comprehensive selection of over 80 signaling molecules, including cytokines, growth factors, and miRNA. Because of this concentrated range of factors, RPA is estimated to be up to 1,000 times more potent than PRP. This potency is attributed to the diversity and density of the regenerative factors present in the array, which work to “reprogram” the local environment of damaged tissues and activate the body’s innate healing capabilities.

Clinicians utilize RPA to support a wide range of health concerns. The specific bioactive molecules found within the RPA array—such as TGF-beta and various interleukins—have been a primary focus of peer-reviewed scientific literature regarding musculoskeletal repair, neurological health, and the management of endocrine and autoimmune pathways. By delivering these signaling proteins, RPA helps manage the local environment to support functional recovery and systemic wellness.

Every Genesis® product is ethically sourced from pristine placentas donated following healthy, scheduled, live C-section births. RPA is produced in an FDA-registered facility that follows Human Cellular Therapy Tissue Product (HCT/P) standards to ensure the highest levels of purity, safety, and quality.

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