North Florida Bone & Joint Specialists – Advanced Solutions for Musculoskeletal, Autoimmune, and Neurological Health
Brett Smith, M.D., M.Sc., is a board-certified, fellowship-trained orthopedic surgeon specializing in total joint and adult reconstruction at North Florida Bone & Joint Specialists. Dr. Smith’s clinical background is rooted in the foundations of modern orthopedics; he completed his fellowship under Dr. Anthony Hedley, a student of Sir John Charnley, the pioneer of the hip replacement. Dr. Smith’s leadership was further established through his work developing the Total Joint Program at the Andrews Institute for Orthopedics and Sports Medicine, where he served as Medical Director and Chairman of the Executive Committee. His practice focus centers on high-quality outcomes through both surgical precision and advanced restorative interventions.
Jason Lunsford, D.Sc, PA-C, works in coordination with Dr. Smith, bringing a background in orthopedic trauma and systemic recovery. Dr. Lunsford completed a postgraduate Doctoral fellowship in orthopedic surgery at the San Antonio Military Medical Center (SAMMC), a Level 1 trauma center. His experience treating the military population and Wounded Warriors has provided him with extensive expertise in musculoskeletal oncology, complex trauma, and joint replacement. Dr. Lunsford specializes in minimally invasive joint injections and IV therapies designed to address both orthopedic and systemic conditions, including chronic pain management and neurological health.
At North Florida Bone & Joint Specialists, the team bridges the gap between surgical expertise and restorative medicine. Their clinical scope addresses the biological factors associated with autoimmune dysfunction and GI health, while offering protocols for anti-aging and long-term vitality. By focusing on the root causes of physical limitation, they provide patients in Pensacola, Gulf Breeze, and Ft. Walton Beach with a structured path to functional recovery.
Genesis® Regenerative Protein Arrays
In their clinical practice, Dr. Smith and Dr. Lunsford utilize the Genesis® Regenerative Protein Array (RPA) as a sophisticated modality for tissue support and cellular communication. RPA is a “generation beyond” conventional therapies like Platelet-Rich Plasma (PRP) or stem cells. It is an acellular product, meaning it contains no whole cells or DNA. This design significantly reduces the potential for adverse immune reactions or inflammatory spikes, providing a highly refined option for patients seeking advanced restorative support.
The primary mechanism of RPA is paracrine signaling—a biological process where bioactive molecules deliver a biochemical “blueprint” that communicates with the patient’s own cells to coordinate a healing response.
Each array contains a comprehensive selection of over 80 signaling molecules, including cytokines, growth factors, and miRNA. Because of the density and diversity of these regenerative factors, RPA is estimated to be up to 1,000 times more potent than PRP. This potency allows the array to help “reprogram” the local environment of damaged tissues, activating and orchestrating the body’s innate healing capabilities without the introduction of foreign biological material.
The bioactive molecules within the RPA array—such as TGF-beta and various interleukins—are the focus of extensive peer-reviewed scientific literature regarding their roles in cellular repair and anti-inflammatory pathways. By delivering these signaling proteins, RPA supports the body’s natural ability to manage the local tissue environment, which is essential for maintaining systemic wellness and functional recovery.
