{"id":203,"date":"2026-06-30T18:51:23","date_gmt":"2026-06-30T18:51:23","guid":{"rendered":"https:\/\/ecommerceseo.us\/stemcellhawaii\/?post_type=treatments&#038;p=203"},"modified":"2026-07-07T22:26:17","modified_gmt":"2026-07-07T22:26:17","slug":"platelet-rich-plasma-prp-therapy","status":"publish","type":"treatments","link":"https:\/\/ecommerceseo.us\/stemcellhawaii\/treatments\/platelet-rich-plasma-prp-therapy\/","title":{"rendered":"Platelet Rich Plasma (PRP) Therapy"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1j50s0-c7c2c178c638276b17322ae2f54e5dd6\">\n.avia-section.av-1j50s0-c7c2c178c638276b17322ae2f54e5dd6{\nbackground-repeat:no-repeat;\nbackground-image:url(https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/Platelets.jpg);\nbackground-position:50% 50%;\nbackground-attachment:scroll;\n}\n.avia-section.av-1j50s0-c7c2c178c638276b17322ae2f54e5dd6 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><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr0wz7ls-9b1214c841e91e736c94d251436b134d\">\n#top .av-special-heading.av-mr0wz7ls-9b1214c841e91e736c94d251436b134d{\npadding-bottom:10px;\ncolor:#ffffff;\nfont-size:55px;\n}\nbody .av-special-heading.av-mr0wz7ls-9b1214c841e91e736c94d251436b134d .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr0wz7ls-9b1214c841e91e736c94d251436b134d .av-special-heading-tag{\nfont-size:55px;\n}\n.av-special-heading.av-mr0wz7ls-9b1214c841e91e736c94d251436b134d .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-mr0wz7ls-9b1214c841e91e736c94d251436b134d .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr0wz7ls-9b1214c841e91e736c94d251436b134d .av-special-heading-tag{\nfont-size:35px;\n}\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr0wz7ls-9b1214c841e91e736c94d251436b134d .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr0wz7ls-9b1214c841e91e736c94d251436b134d av-special-heading-h1 custom-color-heading blockquote modern-quote  avia-builder-el-2  el_before_av_textblock  avia-builder-el-first  text-shadow av-inherit-size'><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >Platelet Rich Plasma (PRP) Therapy<\/h1><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr0wzfnm-77939d1f452d9a744e71de8c724d5e99\">\n#top .av_textblock_section.av-mr0wzfnm-77939d1f452d9a744e71de8c724d5e99 .avia_textblock{\nfont-size:20px;\ncolor:#ffffff;\n}\n<\/style>\n<section  class='av_textblock_section av-mr0wzfnm-77939d1f452d9a744e71de8c724d5e99 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock text-shadow av_inherit_color'  itemprop=\"text\" ><p>Amplifies the body&#8217;s natural ability to heal without surgery or pharmaceuticals.<\/p>\n<\/div><\/section><br \/>\n<div  class='avia-buttonrow-wrap av-19f20g-ffd39f21876dd8dde6066c5a69c3a6e5 avia-buttonrow-left  avia-builder-el-4  el_after_av_textblock  el_before_av_buttonrow  av-mini-hide'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-13595k-a68ee9131c24a4cb10978b5b8984dbb5\">\n#top #wrap_all .avia-button.av-13595k-a68ee9131c24a4cb10978b5b8984dbb5{\nbackground-color:#30a698;\nborder-color:#30a698;\ncolor:#ffffff;\nborder-style:solid;\nborder-width:2px 2px 2px 2px;\ntransition:all 0.4s ease-in-out;\nmargin-bottom:5px;\nmargin-right:5px;\n}\n#top #wrap_all .avia-button.av-13595k-a68ee9131c24a4cb10978b5b8984dbb5:hover{\ncolor:white;\ntransition:all 0.4s ease-in-out;\n}\n#top #wrap_all 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.avia-svg-icon svg:first-child{\nfill:white;\nstroke:white;\n}\n<\/style>\n<a href='https:\/\/ecommerceseo.us\/stemcellhawaii\/contact\/'  class='avia-button av-g5jbc-97be3444d50461816fa231e5fc651944 avia-icon_select-no avia-size-large avia-color-light'   aria-label=\"Contact Us\"><span class='avia_iconbox_title' >Contact Us<\/span><span class='avia_button_background avia-button avia-color-theme-color-highlight' ><\/span><\/a>\n<\/div><\/p><\/div><div  class='flex_column av-9yr94-810d19b1096b26e2a90e3d3361a58a7b av_one_half  avia-builder-el-6  el_after_av_one_half  avia-builder-el-last  flex_column_div  '     ><\/div>\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div><div id='av_section_2'  class='avia-section av-mr0x1xmx-6df2d2ae14ee61ddd71af0769f736de6 main_color avia-section-large avia-no-border-styling  avia-builder-el-7  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-203'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-8qyv4-aa0896f8e4aac08971fcaa4f33e5e3cf av_one_full  avia-builder-el-8  el_before_av_one_half  avia-builder-el-first  mobile-text first flex_column_div av-animated-generic bottom-to-top  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9monf4-a058e35ef950c22f347f9a0b99734cf4\">\n#top .av-special-heading.av-mr9monf4-a058e35ef950c22f347f9a0b99734cf4{\npadding-bottom:10px;\nfont-size:40px;\n}\nbody .av-special-heading.av-mr9monf4-a058e35ef950c22f347f9a0b99734cf4 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr9monf4-a058e35ef950c22f347f9a0b99734cf4 .av-special-heading-tag{\nfont-size:40px;\n}\n.av-special-heading.av-mr9monf4-a058e35ef950c22f347f9a0b99734cf4 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr9monf4-a058e35ef950c22f347f9a0b99734cf4 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr9monf4-a058e35ef950c22f347f9a0b99734cf4 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr9monf4-a058e35ef950c22f347f9a0b99734cf4 av-special-heading-h2 blockquote modern-quote  avia-builder-el-9  el_before_av_heading  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >The Evolution of Platelet-Rich Plasma: Moving Beyond Platelet Counts<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mrb7x0wm-d3707bfb16497d7d78a1bacec310fb12\">\n#top .av-special-heading.av-mrb7x0wm-d3707bfb16497d7d78a1bacec310fb12{\npadding-bottom:10px;\nfont-size:26px;\n}\nbody .av-special-heading.av-mrb7x0wm-d3707bfb16497d7d78a1bacec310fb12 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mrb7x0wm-d3707bfb16497d7d78a1bacec310fb12 .av-special-heading-tag{\nfont-size:26px;\n}\n.av-special-heading.av-mrb7x0wm-d3707bfb16497d7d78a1bacec310fb12 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mrb7x0wm-d3707bfb16497d7d78a1bacec310fb12 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mrb7x0wm-d3707bfb16497d7d78a1bacec310fb12 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mrb7x0wm-d3707bfb16497d7d78a1bacec310fb12 av-special-heading-h3 blockquote modern-quote  avia-builder-el-10  el_after_av_heading  el_before_av_textblock  av-inherit-size'><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >PRP<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-ajmtn-af26ff54099fdcf90f9d6ea4afb81015 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>PRP stands for Platelet Rich Plasma. Platelet rich plasma is made from a fresh sample of your own blood. The sample is specially prepared to separate out, concentrate and then stimulate the platelets, which then are injected.<\/p>\n<p>Platelets are powerful particles in the blood that normally concentrate at an area of injury and set off a signaling cascade that tells the body to heal or rejuvenate a damaged area. Some of the powerful signaling molecules that platelets make include Platelet-Derived Growth Factor (PDGF) \u2013 Responsible for cell growth and division, Vascular Endothelial Growth Factor (VEGF) \u2013 Responsible for creation of new blood vessels and capillaries, Transforming Growth Factor (TGF) \u2013 Controls cell growth and cell differentiation, and Epidermal Growth Factor (EGF) \u2013 Regulating cell growth and differentiation.<\/p>\n<p>The field of Orthobiologics, using biologically active materials in orthopedic medicine to initiate growth, repair and regeneration, began with the invention of PRP therapy in surgical orthopedic cases. Today the field of Orthobiologics has blossomed into one of the fastest growing medical specialties, and has evolved beyond the OR into outpatient clinicals using pinpoint injection under ultrasound or X ray guidance to deliver the Orthobiologic treatment precisely into the target tissue within a short clinic visit. PRP is at the center of this revolution based on its affordable cost, safety, minimal invasiveness, and its clinical results that are consistently demonstrated to be above the standard of care across a wide variety of musculoskeletal conditions.<\/p>\n<\/div><\/section><\/p><\/div><div class='flex_column_table av-mr9n8qhc-e04c9ae04d34645d809479ae7deaf8b7 sc-av_one_half av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9n8qhc-e04c9ae04d34645d809479ae7deaf8b7\">\n.flex_column.av-mr9n8qhc-e04c9ae04d34645d809479ae7deaf8b7{\nwidth:48%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-mr9n8qhc-e04c9ae04d34645d809479ae7deaf8b7 .av-flex-placeholder{\nwidth:4%;\n}\n<\/style>\n<div  class='flex_column av-mr9n8qhc-e04c9ae04d34645d809479ae7deaf8b7 av_one_half  avia-builder-el-12  el_after_av_one_full  el_before_av_one_half  mobile-text first flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9mp8j2-72b4c8710dbfb0b5ef82bf186eacb618\">\n#top .av-special-heading.av-mr9mp8j2-72b4c8710dbfb0b5ef82bf186eacb618{\npadding-bottom:10px;\nfont-size:26px;\n}\nbody .av-special-heading.av-mr9mp8j2-72b4c8710dbfb0b5ef82bf186eacb618 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr9mp8j2-72b4c8710dbfb0b5ef82bf186eacb618 .av-special-heading-tag{\nfont-size:26px;\n}\n.av-special-heading.av-mr9mp8j2-72b4c8710dbfb0b5ef82bf186eacb618 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr9mp8j2-72b4c8710dbfb0b5ef82bf186eacb618 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr9mp8j2-72b4c8710dbfb0b5ef82bf186eacb618 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr9mp8j2-72b4c8710dbfb0b5ef82bf186eacb618 av-special-heading-h2 blockquote modern-quote  avia-builder-el-13  el_before_av_textblock  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >A New Perspective on PRP Therapy<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-av_textblock-027aa0d5e2565f1df3ffea92ee1b3453 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>While Platelet-Rich Plasma (PRP) has become one of the most widely used regenerative therapies in modern Orthobiologics, for years, clinicians have focused on two primary measures of PRP quality: platelet concentration and total platelet dose.<\/p>\n<p>Yet as the use of PRP has expanded, current evidence suggests that platelet number and concentration alone may not fully explain the biological activity of a PRP preparation. Instead, the platelets\u2019 growth factor cargo, the composition of the surrounding plasma, and the timing of their release all appear to influence the final therapeutic effect.<\/p>\n<p>As a result, the field is gradually shifting from a purely quantitative model toward a more functional and comprehensive understanding of PRP as a dynamic biologic system.<\/p>\n<\/div><\/section><\/p><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2qec2r-0f64b170525de0c3fc659828bffa0b43\">\n.flex_column.av-2qec2r-0f64b170525de0c3fc659828bffa0b43{\nwidth:48%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-2qec2r-0f64b170525de0c3fc659828bffa0b43 .av-flex-placeholder{\nwidth:4%;\n}\n<\/style>\n<div  class='flex_column av-2qec2r-0f64b170525de0c3fc659828bffa0b43 av_one_half  avia-builder-el-15  el_after_av_one_half  avia-builder-el-last  mobile-text flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9ni013-aaf8f6aa7a24d3ff03afcef70725c0a1\">\n.avia-image-container.av-mr9ni013-aaf8f6aa7a24d3ff03afcef70725c0a1 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr9ni013-aaf8f6aa7a24d3ff03afcef70725c0a1 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr9ni013-aaf8f6aa7a24d3ff03afcef70725c0a1 av-styling- avia-align-center  avia-builder-el-16  avia-builder-el-no-sibling  imageshadow'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-317 avia-img-lazy-loading-not-317 avia_image ' src=\"https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/prp-evolution-beyond-platelet-counts.webp\" alt='Visual representation of PRP as a dynamic biologic system including plasma composition and cellular interaction' title='prp-evolution-beyond-platelet-counts'  height=\"417\" width=\"580\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/prp-evolution-beyond-platelet-counts.webp 580w, https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/prp-evolution-beyond-platelet-counts-300x216.webp 300w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/div><\/div><\/div><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><\/div><\/div><\/div><!-- close content main div --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-4uslc3-fee6b9ee929e396eb6636313b06124b9\">\n.avia-section.av-4uslc3-fee6b9ee929e396eb6636313b06124b9{\nbackground-color:#2c605a;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_3'  class='avia-section av-4uslc3-fee6b9ee929e396eb6636313b06124b9 main_color avia-section-large avia-no-border-styling  avia-builder-el-17  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-203'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-4skimb-544d6d010c9293a4beb85bd7574d60c2 av_one_full  avia-builder-el-18  el_before_av_one_third  avia-builder-el-first  first flex_column_div av-animated-generic bottom-to-top  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr1433vv-2f456735b7371e9332cfc64645545160\">\n#top .av-special-heading.av-mr1433vv-2f456735b7371e9332cfc64645545160{\npadding-bottom:10px;\ncolor:#ffffff;\nfont-size:45px;\n}\nbody .av-special-heading.av-mr1433vv-2f456735b7371e9332cfc64645545160 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr1433vv-2f456735b7371e9332cfc64645545160 .av-special-heading-tag{\nfont-size:45px;\n}\n.av-special-heading.av-mr1433vv-2f456735b7371e9332cfc64645545160 .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-mr1433vv-2f456735b7371e9332cfc64645545160 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr1433vv-2f456735b7371e9332cfc64645545160 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr1433vv-2f456735b7371e9332cfc64645545160 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr1433vv-2f456735b7371e9332cfc64645545160 av-special-heading-h2 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-19  el_before_av_textblock  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Next-Generation Orthobiologics<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9mr402-f9cd09dac2192737353bb9677d89e00a\">\n#top .av_textblock_section.av-mr9mr402-f9cd09dac2192737353bb9677d89e00a .avia_textblock{\ncolor:#ffffff;\ntext-align:center;\n}\n<\/style>\n<section  class='av_textblock_section av-mr9mr402-f9cd09dac2192737353bb9677d89e00a '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock av_inherit_color'  itemprop=\"text\" ><p>Emerging technologies seek to further refine the biologic product before reinjection through additional processing steps intended to optimize timing, reduce unwanted components, and concentrate beneficial cell signals.<\/p>\n<p>These approaches generally involve three major stages:<\/p>\n<\/div><\/section><\/p><\/div><div class='flex_column_table av-4jj443-b4718cbc19d2de8be4f3b367d008ecab sc-av_one_third av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-4jj443-b4718cbc19d2de8be4f3b367d008ecab\">\n#top .flex_column_table.av-equal-height-column-flextable.av-4jj443-b4718cbc19d2de8be4f3b367d008ecab{\nmargin-top:20px;\nmargin-bottom:0px;\n}\n.flex_column.av-4jj443-b4718cbc19d2de8be4f3b367d008ecab{\nwidth:31.333333333333%;\nmargin-left:0;\npadding:15px 15px 15px 15px;\nbackground-color:rgba(255,255,255,0.08);\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-4jj443-b4718cbc19d2de8be4f3b367d008ecab .av-flex-placeholder{\nwidth:3%;\n}\n<\/style>\n<div  class='flex_column av-4jj443-b4718cbc19d2de8be4f3b367d008ecab av_one_third  avia-builder-el-21  el_after_av_one_full  el_before_av_one_third  shadowbox first flex_column_table_cell av-equal-height-column av-align-top av-animated-generic zoom-in  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-49kdrf-da74663d9cf01fb87b8bd10120c563f6\">\n#top .av-special-heading.av-49kdrf-da74663d9cf01fb87b8bd10120c563f6{\nmargin:0 0 0 0;\npadding-bottom:10px;\ncolor:#ffffff;\nfont-size:22px;\n}\nbody .av-special-heading.av-49kdrf-da74663d9cf01fb87b8bd10120c563f6 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-49kdrf-da74663d9cf01fb87b8bd10120c563f6 .av-special-heading-tag{\nfont-size:22px;\npadding:0 15px 0 15px;\n}\n.av-special-heading.av-49kdrf-da74663d9cf01fb87b8bd10120c563f6 .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-49kdrf-da74663d9cf01fb87b8bd10120c563f6 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-49kdrf-da74663d9cf01fb87b8bd10120c563f6 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-49kdrf-da74663d9cf01fb87b8bd10120c563f6 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-49kdrf-da74663d9cf01fb87b8bd10120c563f6 av-special-heading-h4 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-22  avia-builder-el-no-sibling  titlespace av-inherit-size'><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >Platelet activation<\/h4><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2kr59f-744f5832c9b495f565639da203bcf3b9\">\n#top .flex_column_table.av-equal-height-column-flextable.av-2kr59f-744f5832c9b495f565639da203bcf3b9{\nmargin-top:20px;\nmargin-bottom:0px;\n}\n.flex_column.av-2kr59f-744f5832c9b495f565639da203bcf3b9{\nwidth:31.333333333333%;\nmargin-left:0;\npadding:15px 15px 15px 15px;\nbackground-color:rgba(255,255,255,0.08);\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-2kr59f-744f5832c9b495f565639da203bcf3b9 .av-flex-placeholder{\nwidth:3%;\n}\n<\/style>\n<div  class='flex_column av-2kr59f-744f5832c9b495f565639da203bcf3b9 av_one_third  avia-builder-el-23  el_after_av_one_third  el_before_av_one_third  shadowbox flex_column_table_cell av-equal-height-column av-align-top av-animated-generic zoom-in  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9mu83m-ac5460151fd015cc71c2de55207db798\">\n#top .av-special-heading.av-mr9mu83m-ac5460151fd015cc71c2de55207db798{\nmargin:0 0 0 0;\npadding-bottom:10px;\ncolor:#ffffff;\nfont-size:22px;\n}\nbody .av-special-heading.av-mr9mu83m-ac5460151fd015cc71c2de55207db798 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr9mu83m-ac5460151fd015cc71c2de55207db798 .av-special-heading-tag{\nfont-size:22px;\npadding:0 15px 0 15px;\n}\n.av-special-heading.av-mr9mu83m-ac5460151fd015cc71c2de55207db798 .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-mr9mu83m-ac5460151fd015cc71c2de55207db798 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr9mu83m-ac5460151fd015cc71c2de55207db798 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr9mu83m-ac5460151fd015cc71c2de55207db798 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr9mu83m-ac5460151fd015cc71c2de55207db798 av-special-heading-h4 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-24  avia-builder-el-no-sibling  titlespace av-inherit-size'><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >Filtration<\/h4><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2dqxsb-784b3c63cbba3a2cc66d97ebfca4f07f\">\n#top .flex_column_table.av-equal-height-column-flextable.av-2dqxsb-784b3c63cbba3a2cc66d97ebfca4f07f{\nmargin-top:20px;\nmargin-bottom:0px;\n}\n.flex_column.av-2dqxsb-784b3c63cbba3a2cc66d97ebfca4f07f{\nwidth:31.333333333333%;\nmargin-left:0;\npadding:15px 15px 15px 15px;\nbackground-color:rgba(255,255,255,0.08);\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-2dqxsb-784b3c63cbba3a2cc66d97ebfca4f07f .av-flex-placeholder{\nwidth:3%;\n}\n<\/style>\n<div  class='flex_column av-2dqxsb-784b3c63cbba3a2cc66d97ebfca4f07f av_one_third  avia-builder-el-25  el_after_av_one_third  el_before_av_one_full  shadowbox flex_column_table_cell av-equal-height-column av-align-top av-animated-generic zoom-in  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9mud94-e23de9e2d3cb6355c0beaa1466335097\">\n#top .av-special-heading.av-mr9mud94-e23de9e2d3cb6355c0beaa1466335097{\nmargin:0 0 0 0;\npadding-bottom:10px;\ncolor:#ffffff;\nfont-size:22px;\n}\nbody .av-special-heading.av-mr9mud94-e23de9e2d3cb6355c0beaa1466335097 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr9mud94-e23de9e2d3cb6355c0beaa1466335097 .av-special-heading-tag{\nfont-size:22px;\npadding:0 15px 0 15px;\n}\n.av-special-heading.av-mr9mud94-e23de9e2d3cb6355c0beaa1466335097 .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-mr9mud94-e23de9e2d3cb6355c0beaa1466335097 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr9mud94-e23de9e2d3cb6355c0beaa1466335097 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr9mud94-e23de9e2d3cb6355c0beaa1466335097 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr9mud94-e23de9e2d3cb6355c0beaa1466335097 av-special-heading-h4 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-26  avia-builder-el-no-sibling  titlespace av-inherit-size'><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >Plasma protein concentration<\/h4><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><div  class='flex_column av-86xfv-8ad385020b4e43b4959ffbeb343e484c av_one_full  avia-builder-el-27  el_after_av_one_third  avia-builder-el-last  first flex_column_div av-animated-generic bottom-to-top  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9muwyb-9dc2370ea748dc08bdd0b06f91ccd9a1\">\n#top .av_textblock_section.av-mr9muwyb-9dc2370ea748dc08bdd0b06f91ccd9a1 .avia_textblock{\ncolor:#ffffff;\ntext-align:center;\n}\n<\/style>\n<section  class='av_textblock_section av-mr9muwyb-9dc2370ea748dc08bdd0b06f91ccd9a1 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock av_inherit_color'  itemprop=\"text\" ><p>At Hawaii Island Regenerative Medicine and Stem Cell therapy, our next generation PRP is designed to optimize not only platelet count, but also concentration and purification of growth factors, along with specifically timed platelet activation mechanisms, to optimize PRP as a complex functional regenerative medicine therapy.<\/p>\n<\/div><\/section><\/div>\n<\/p>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_4'  class='avia-section av-2164uz-360ced32a5b493bd17723a77a7ccc592 main_color avia-section-large avia-no-border-styling  avia-builder-el-29  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-203'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column_table av-mr9n8j0s-7eb7c06141c367c180e6242da3dbb9b1 sc-av_one_half av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9n8j0s-7eb7c06141c367c180e6242da3dbb9b1\">\n.flex_column.av-mr9n8j0s-7eb7c06141c367c180e6242da3dbb9b1{\nwidth:48%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-mr9n8j0s-7eb7c06141c367c180e6242da3dbb9b1 .av-flex-placeholder{\nwidth:4%;\n}\n<\/style>\n<div  class='flex_column av-mr9n8j0s-7eb7c06141c367c180e6242da3dbb9b1 av_one_half  avia-builder-el-30  el_before_av_one_half  avia-builder-el-first  mobile-text first flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9mw2tr-e12be4a1e481b4b879ed21f404c47117\">\n#top .av-special-heading.av-mr9mw2tr-e12be4a1e481b4b879ed21f404c47117{\npadding-bottom:10px;\nfont-size:40px;\n}\nbody .av-special-heading.av-mr9mw2tr-e12be4a1e481b4b879ed21f404c47117 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr9mw2tr-e12be4a1e481b4b879ed21f404c47117 .av-special-heading-tag{\nfont-size:40px;\n}\n.av-special-heading.av-mr9mw2tr-e12be4a1e481b4b879ed21f404c47117 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr9mw2tr-e12be4a1e481b4b879ed21f404c47117 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr9mw2tr-e12be4a1e481b4b879ed21f404c47117 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr9mw2tr-e12be4a1e481b4b879ed21f404c47117 av-special-heading-h2 blockquote modern-quote  avia-builder-el-31  el_before_av_textblock  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Step 1: Platelet Activation<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-mr9mwbyc-b306b0b7eae01d9e0b1d282420baab89 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Platelets are often described as the active ingredient in PRP, but a more accurate description is that they function as biologic delivery vehicles.<\/p>\n<p>Within platelet alpha granules resides a sophisticated collection of signaling molecules that help coordinate tissue healing. These include platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-\u03b2), vascular endothelial growth factor (VEGF), along with other numerous cytokines and regulatory proteins.<\/p>\n<p>Importantly, biologic signaling is highly regulated. The effectiveness of PRP depends not only on the amount of growth factors present, but also on the timing of how those signals are delivered since the release pattern of growth factors affects how cells respond. Different phases of healing require different signals, making release kinetics an important consideration.<\/p>\n<\/div><\/section><\/p><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1vlvr7-996868a88e1a775bd7a064637050b7c4\">\n.flex_column.av-1vlvr7-996868a88e1a775bd7a064637050b7c4{\nwidth:48%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-1vlvr7-996868a88e1a775bd7a064637050b7c4 .av-flex-placeholder{\nwidth:4%;\n}\n<\/style>\n<div  class='flex_column av-1vlvr7-996868a88e1a775bd7a064637050b7c4 av_one_half  avia-builder-el-33  el_after_av_one_half  el_before_av_one_full  mobile-text flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9nj272-419f9ee37d8b9ac0a822555fb7123ea7\">\n.avia-image-container.av-mr9nj272-419f9ee37d8b9ac0a822555fb7123ea7 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr9nj272-419f9ee37d8b9ac0a822555fb7123ea7 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr9nj272-419f9ee37d8b9ac0a822555fb7123ea7 av-styling- avia-align-center  avia-builder-el-34  avia-builder-el-no-sibling  imageshadow'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-316 avia-img-lazy-loading-not-316 avia_image ' src=\"https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/platelet-activation-prp-process.webp\" alt='Infographic showing timing and release kinetics of growth factors in platelet rich plasma therapy' title='platelet-activation-prp-process'  height=\"463\" width=\"580\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/platelet-activation-prp-process.webp 580w, https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/platelet-activation-prp-process-300x239.webp 300w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/div><\/div><\/div><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><div  class='flex_column av-1ovgwj-69938f8fbe0e4d61dde12eb4fc3670d7 av_one_full  avia-builder-el-35  el_after_av_one_half  avia-builder-el-last  mobile-text first flex_column_div av-animated-generic bottom-to-top  column-top-margin'     ><section  class='av_textblock_section av-mr9mwr71-c1437a74bf24bcb09cac73b3ea093054 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>The platelet activation process determines when and how platelets release their stored growth factors which in turn influences the spatial and temporal distribution of regenerative signals after injection.<\/p>\n<p>Over the years, a variety of activation methods have been developed, including calcium chloride activation, thrombin activation, freeze-thaw platelet lysates, collagen-based activation, and surface-mediated activation systems. Each approach influences the timing and magnitude of growth factor release.<\/p>\n<p>At Hawaii Island Regenerative medicine and Stem cell therapy, our plkatelt activcatio system involves activation through contact with specialized glass surfaces. When platelets encounter negatively charged glass, physiologic activation pathways are triggered, leading to platelet adhesion, aggregation, and degranulation. This process stimulates the release of important regenerative mediators including PDGF, TGF-\u03b2, and VEGF. Our system also times the rate of release of these mediators, to optimize the immediate and long term effects of the pkatelts oince injected<\/p>\n<p>With the proprietary system we are using, our tesearch has demonstrated increased production of anti-inflammatory mediators such as interleukin-1 receptor antagonist (IL-1Ra), along with elevations in IL-10 and multiple regenerative growth factors. IN addition, while some pro-inflammatory cytokines may also increase during incubation, the overall cytokine profile tends to favor an anti-inflammatory environment. By combining immediatet activation with longer term platelet activation, the regenerative process inside the inurued target tissue is optimized.<\/p>\n<\/div><\/section><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9mzdxq-6e4f52249f69ee3abf28f40b54764721\">\n.avia-section.av-mr9mzdxq-6e4f52249f69ee3abf28f40b54764721{\nbackground-color:#2c2f34;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_5'  class='avia-section av-mr9mzdxq-6e4f52249f69ee3abf28f40b54764721 main_color avia-section-large avia-no-border-styling  avia-builder-el-37  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-203'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column_table av-mr9n8bdr-0a5a4398dd1df3004916bebdfeefe451 sc-av_one_half av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9n8bdr-0a5a4398dd1df3004916bebdfeefe451\">\n.flex_column.av-mr9n8bdr-0a5a4398dd1df3004916bebdfeefe451{\nwidth:48%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-mr9n8bdr-0a5a4398dd1df3004916bebdfeefe451 .av-flex-placeholder{\nwidth:4%;\n}\n<\/style>\n<div  class='flex_column av-mr9n8bdr-0a5a4398dd1df3004916bebdfeefe451 av_one_half  avia-builder-el-38  el_before_av_one_half  avia-builder-el-first  first flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9myuk5-8aa3df08296b6afadb6a6af428db33de\">\n#top .av-special-heading.av-mr9myuk5-8aa3df08296b6afadb6a6af428db33de{\npadding-bottom:10px;\ncolor:#ffffff;\nfont-size:40px;\n}\nbody .av-special-heading.av-mr9myuk5-8aa3df08296b6afadb6a6af428db33de .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr9myuk5-8aa3df08296b6afadb6a6af428db33de .av-special-heading-tag{\nfont-size:40px;\n}\n.av-special-heading.av-mr9myuk5-8aa3df08296b6afadb6a6af428db33de .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-mr9myuk5-8aa3df08296b6afadb6a6af428db33de .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr9myuk5-8aa3df08296b6afadb6a6af428db33de .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr9myuk5-8aa3df08296b6afadb6a6af428db33de .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr9myuk5-8aa3df08296b6afadb6a6af428db33de av-special-heading-h2 custom-color-heading blockquote modern-quote  avia-builder-el-39  el_before_av_textblock  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Step 2: Filtration and Product Refinement<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9mz1gf-1c9071a1d66157b3cb5282a83bf6d7b1\">\n#top .av_textblock_section.av-mr9mz1gf-1c9071a1d66157b3cb5282a83bf6d7b1 .avia_textblock{\ncolor:#ffffff;\n}\n<\/style>\n<section  class='av_textblock_section av-mr9mz1gf-1c9071a1d66157b3cb5282a83bf6d7b1 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock av_inherit_color'  itemprop=\"text\" ><p>Filtration serves as an additional processing step designed to improve the consistency of the final orthobiologic product.\u00a0 Unlike our comepteitos, at Hawaii Island Regenertaive medicine and Stem Cell therapy, ouy standr4d next generatiojn PRP product includes a step of filtration and product refinement.<\/p>\n<p>Potential benefits include:<\/p>\n<ul>\n<li aria-level=\"1\">Reduction of cellular debris<\/li>\n<li aria-level=\"1\">Removal of unwanted particulate material<\/li>\n<li aria-level=\"1\">Improved injectability<\/li>\n<li aria-level=\"1\">Enhanced product uniformity<\/li>\n<li aria-level=\"1\">Reduction of certain inflammatory cellular components<\/li>\n<\/ul>\n<\/div><\/section><\/p><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1k6twz-705469c2e027f7c904a67b4fe8bff119\">\n.flex_column.av-1k6twz-705469c2e027f7c904a67b4fe8bff119{\nwidth:48%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-1k6twz-705469c2e027f7c904a67b4fe8bff119 .av-flex-placeholder{\nwidth:4%;\n}\n<\/style>\n<div  class='flex_column av-1k6twz-705469c2e027f7c904a67b4fe8bff119 av_one_half  avia-builder-el-41  el_after_av_one_half  el_before_av_one_full  mobile-text flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9njuzt-0a36f830b2c703e0387f7dd0ecd9f912\">\n.avia-image-container.av-mr9njuzt-0a36f830b2c703e0387f7dd0ecd9f912 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr9njuzt-0a36f830b2c703e0387f7dd0ecd9f912 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr9njuzt-0a36f830b2c703e0387f7dd0ecd9f912 av-styling- avia-align-center  avia-builder-el-42  avia-builder-el-no-sibling  imageshadow'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-318 avia-img-lazy-loading-not-318 avia_image ' src=\"https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/prp-filtration-process-refinement.webp\" alt='Medical illustration of advanced PRP processing including filtration for enhanced orthobiologic quality' title='prp-filtration-process-refinement'  height=\"503\" width=\"580\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/prp-filtration-process-refinement.webp 580w, https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/prp-filtration-process-refinement-300x260.webp 300w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/div><\/div><\/div><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><div  class='flex_column av-1g641f-a5a241f9eefb0cb1e4c6a63987d7fab4 av_one_full  avia-builder-el-43  el_after_av_one_half  avia-builder-el-last  first flex_column_div av-animated-generic bottom-to-top  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9mz86t-797561a6d25a1d616e88a8517e501e4a\">\n#top .av_textblock_section.av-mr9mz86t-797561a6d25a1d616e88a8517e501e4a .avia_textblock{\ncolor:#ffffff;\n}\n<\/style>\n<section  class='av_textblock_section av-mr9mz86t-797561a6d25a1d616e88a8517e501e4a '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock av_inherit_color'  itemprop=\"text\" ><p>The most refined platelet isolate is called platelet lysate, where after activation, all of the cellular component of the platelets are removed. Platelet lysate is typically used for sensitive areas including nerve hydro-dissection.<\/p>\n<p>In summary, filtration and product refinement can help create a more controlled biologic environment by refining the cellular and physical characteristics of the final preparation, giving us a higher degree of flexibility and discernment when choosing a final Orthobiologic product, depending on the individualized needs of the patient. Competitors using traditional model of PRP preparation often omit this crucial step.<\/p>\n<\/div><\/section><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_6'  class='avia-section av-1aryub-121a506af320c7f7bfb0cbbeddf79d7f main_color avia-section-large avia-no-border-styling  avia-builder-el-45  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-203'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column_table av-mr9n80e1-fae3c368e70be85ab13340965aa520bd sc-av_one_half av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9n80e1-fae3c368e70be85ab13340965aa520bd\">\n.flex_column.av-mr9n80e1-fae3c368e70be85ab13340965aa520bd{\nwidth:48%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-mr9n80e1-fae3c368e70be85ab13340965aa520bd .av-flex-placeholder{\nwidth:4%;\n}\n<\/style>\n<div  class='flex_column av-mr9n80e1-fae3c368e70be85ab13340965aa520bd av_one_half  avia-builder-el-46  el_before_av_one_half  avia-builder-el-first  mobile-text first flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9mztfh-ea15edbcc6c67ac1c5076ba2c71c458d\">\n#top .av-special-heading.av-mr9mztfh-ea15edbcc6c67ac1c5076ba2c71c458d{\npadding-bottom:10px;\nfont-size:40px;\n}\nbody .av-special-heading.av-mr9mztfh-ea15edbcc6c67ac1c5076ba2c71c458d .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr9mztfh-ea15edbcc6c67ac1c5076ba2c71c458d .av-special-heading-tag{\nfont-size:40px;\n}\n.av-special-heading.av-mr9mztfh-ea15edbcc6c67ac1c5076ba2c71c458d .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr9mztfh-ea15edbcc6c67ac1c5076ba2c71c458d .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr9mztfh-ea15edbcc6c67ac1c5076ba2c71c458d .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr9mztfh-ea15edbcc6c67ac1c5076ba2c71c458d av-special-heading-h2 blockquote modern-quote  avia-builder-el-47  el_before_av_textblock  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Step 3: Plasma Protein Concentration<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-mr9n106b-3936e98b6d9eade9a1a67eef11336921 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>One of the most significant developments in Orthobiologics involves the concentration of beneficial plasma proteins from platelet-poor plasma (PPP).<\/p>\n<p>Historically, PPP was often considered a secondary byproduct of PRP preparation. Newer research suggests that this fraction may contain important therapeutic molecules that deserve greater attention.<\/p>\n<p>The modern ultrafiltration system we utilize includes polysulfone hollow-fiber membranes to selectively remove plasma water while retaining larger proteins and biologically active molecules. This process can concentrate alpha-2 macroglobulin (A2M), insulin-like growth factor-1 (IGF-1), hepatocyte growth factor (HGF), fibrinogen, cytokines like IL-1Ra (Interleuken-1 receptor Antagonist), along with autologous exosomes containing myriad signaling molecules such as micro RNA and additional regulatory proteins.<\/p>\n<\/div><\/section><\/p><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-157exn-1f303b5cc900b0ea1698c397c6571e03\">\n.flex_column.av-157exn-1f303b5cc900b0ea1698c397c6571e03{\nwidth:48%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-157exn-1f303b5cc900b0ea1698c397c6571e03 .av-flex-placeholder{\nwidth:4%;\n}\n<\/style>\n<div  class='flex_column av-157exn-1f303b5cc900b0ea1698c397c6571e03 av_one_half  avia-builder-el-49  el_after_av_one_half  el_before_av_one_full  mobile-text flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9nkk23-11b9e9d8b880f28c0dabc16a627d1a40\">\n.avia-image-container.av-mr9nkk23-11b9e9d8b880f28c0dabc16a627d1a40 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr9nkk23-11b9e9d8b880f28c0dabc16a627d1a40 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr9nkk23-11b9e9d8b880f28c0dabc16a627d1a40 av-styling- avia-align-center  avia-builder-el-50  avia-builder-el-no-sibling  imageshadow'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-319 avia-img-lazy-loading-not-319 avia_image ' src=\"https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/prp-plasma-protein-concentration.webp\" alt='Visualization of key therapeutic proteins in PRP including A2M IGF-1 HGF and fibrinogen' title='prp-plasma-protein-concentration'  height=\"490\" width=\"580\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/prp-plasma-protein-concentration.webp 580w, https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/prp-plasma-protein-concentration-300x253.webp 300w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/div><\/div><\/div><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><div  class='flex_column av-xcmdn-5c15314bd9c9a4d99eaba08e0ffb4155 av_one_full  avia-builder-el-51  el_after_av_one_half  avia-builder-el-last  mobile-text first flex_column_div av-animated-generic bottom-to-top  column-top-margin'     ><section  class='av_textblock_section av-mr9n16f8-beb9aab72f495b75db6217463a08b2fd '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>A2M is of particular interest because it functions as a broad-spectrum inhibitor of cartilage-degrading enzymes, ie a protease inhibitor, neutralizing multiple matrix metalloproteinases (particularly MMP-13) as well as aggrecanases such as ADAMTS-4 and ADAMTS-5, that contribute to cartilage degradation in osteoarthritis. This in turn may help slow cartilage breakdown and reduce protease-mediated joint degeneration associated with osteoarthritis.<\/p>\n<p>Finally, concentrating the plasma allows us to harness the body\u2019s own (autologious) exosomes. Exosomes are the microscopic signaling vesicles that a stem cell releases in order to orchestrate effects within in the stem cell\u2019s micro environment. Containing thousands of regulatory proteins and micro RNA, exosomes are thought to be the body\u2019s most powerful signals. We estimate a typical PRP to be processed in our office to contain 440 billion autologous exosomes whereas we estimate only 25 million to exist in a standard PRP preparation. That\u2019s over a 17 fold increase.<\/p>\n<p>Overall, by concentrating these beneficial proteins using our unique PRP technology we create a biologically enriched product that moves a generation beyond traditional PRP treatments.<\/p>\n<\/div><\/section><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-p4d97-2ccc1831e5ff79efce23ef6c78a477a8\">\n.avia-section.av-p4d97-2ccc1831e5ff79efce23ef6c78a477a8{\nbackground-color:#2c605a;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_7'  class='avia-section av-p4d97-2ccc1831e5ff79efce23ef6c78a477a8 main_color avia-section-large avia-no-border-styling  avia-builder-el-53  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-203'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-lwyxn-6cd75a3db8b1a521c90b8442c5badd74 av_one_full  avia-builder-el-54  avia-builder-el-no-sibling  first flex_column_div av-animated-generic bottom-to-top  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9n1vov-196f4f0294b07b9aec07b7df9cc557b2\">\n#top .av-special-heading.av-mr9n1vov-196f4f0294b07b9aec07b7df9cc557b2{\npadding-bottom:10px;\ncolor:#ffffff;\nfont-size:45px;\n}\nbody .av-special-heading.av-mr9n1vov-196f4f0294b07b9aec07b7df9cc557b2 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr9n1vov-196f4f0294b07b9aec07b7df9cc557b2 .av-special-heading-tag{\nfont-size:45px;\n}\n.av-special-heading.av-mr9n1vov-196f4f0294b07b9aec07b7df9cc557b2 .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-mr9n1vov-196f4f0294b07b9aec07b7df9cc557b2 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr9n1vov-196f4f0294b07b9aec07b7df9cc557b2 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr9n1vov-196f4f0294b07b9aec07b7df9cc557b2 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr9n1vov-196f4f0294b07b9aec07b7df9cc557b2 av-special-heading-h2 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-55  el_before_av_textblock  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >What This Means for Our Patients<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9n2n98-7c9e8c4f9be69e1caeb86c2764db392b\">\n#top .av_textblock_section.av-mr9n2n98-7c9e8c4f9be69e1caeb86c2764db392b .avia_textblock{\ncolor:#ffffff;\ntext-align:center;\n}\n<\/style>\n<section  class='av_textblock_section av-mr9n2n98-7c9e8c4f9be69e1caeb86c2764db392b '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock av_inherit_color'  itemprop=\"text\" ><p>For patients considering PRP or other Orthobiologic treatments, these advances highlight an important reality: not all PRP preparations are created equal.<\/p>\n<p>Historically, discussions about PRP quality have focused on platelet concentration alone. While platelet dose remains an important factor, emerging research suggests that the biological activity of a PRP preparation may also depend on how the product is processed, activated, filtered, and delivered.<\/p>\n<p>By optimizing growth factor signaling, timing, and concentrating beneficial plasma proteins and autologous exosomes, the next generation of PRPO available at Hawaii Island Regenerative medicine and Stem Cell Therapy targets goes beyond our competitors to target the body\u2019s natural repair processes in a more biologically sophisticated manner.<\/p>\n<p>To see if you can benefit from the next generation in PRP, please contact us to schedule your initial consultation.<\/p>\n<\/div><\/section><\/p><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_8'  class='avia-section av-fl737-39f07932af259247df934cd81b7a88f5 main_color avia-section-large avia-no-border-styling  avia-builder-el-57  el_after_av_section  avia-builder-el-last  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-203'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-a6fij-d977fe46ce0172281faf4a81aa4bf7d4 av_one_full  avia-builder-el-58  avia-builder-el-no-sibling  first flex_column_div av-animated-generic bottom-to-top  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9n3ggg-b3a80a91448d330ad3ce63ceb2d775ff\">\n#top .av-special-heading.av-mr9n3ggg-b3a80a91448d330ad3ce63ceb2d775ff{\npadding-bottom:10px;\nfont-size:40px;\n}\nbody .av-special-heading.av-mr9n3ggg-b3a80a91448d330ad3ce63ceb2d775ff .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr9n3ggg-b3a80a91448d330ad3ce63ceb2d775ff .av-special-heading-tag{\nfont-size:40px;\n}\n.av-special-heading.av-mr9n3ggg-b3a80a91448d330ad3ce63ceb2d775ff .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr9n3ggg-b3a80a91448d330ad3ce63ceb2d775ff .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr9n3ggg-b3a80a91448d330ad3ce63ceb2d775ff .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr9n3ggg-b3a80a91448d330ad3ce63ceb2d775ff av-special-heading-h2 blockquote modern-quote  avia-builder-el-59  el_before_av_toggle_container  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >FAQ<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<div  class='togglecontainer av-mr9n7sb0-4ef595126ea6b9cf279ac44fbc66712c av-minimal-toggle  avia-builder-el-60  el_after_av_heading  el_before_av_heading  toggle_close_all' >\n<section class='av_toggle_section av-mr9n6ot6-6ae03b0e3c6661a3d0552614cdb22f23'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-1' data-fake-id='#toggle-id-1' class='toggler  av-title-above '  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-1' data-slide-speed=\"200\" data-title=\"How is PRP different at Hawaii Island Regenerative Medicine and Stem Cell Therapy?\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: How is PRP different at Hawaii Island Regenerative Medicine and Stem Cell Therapy?\" data-aria_expanded=\"Click to collapse: How is PRP different at Hawaii Island Regenerative Medicine and Stem Cell Therapy?\">How is PRP different at Hawaii Island Regenerative Medicine and Stem Cell Therapy?<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-1' aria-labelledby='toggle-toggle-id-1' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color '  itemprop=\"text\" ><p>Unlike conventional PRP, our PRP platelets are activated in a unique timing sequence to optimize the time response curve. Our PRP is filtered to remove unwanted debris. And finally, our plasma is concentrated as well to deliver a concentration of beneficial plasma proteins. The end result is the optimization of the PRP as a biologically active product for injection.<\/p>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-mr9n75pq-119412d38142502d588957fbdf08d701'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-2' data-fake-id='#toggle-id-2' class='toggler  av-title-above '  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-2' data-slide-speed=\"200\" data-title=\"How does the unique processing with PRP occur?\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: How does the unique processing with PRP occur?\" data-aria_expanded=\"Click to collapse: How does the unique processing with PRP occur?\">How does the unique processing with PRP occur?<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-2' aria-labelledby='toggle-toggle-id-2' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color '  itemprop=\"text\" ><p>The device we use to process patients is called the ExocubeTM, which is FDA cleared and which has been validated in independent research. ExocubeTM is available through our clinic based on our contract with the manufacturer, Plymouth Medical. You can read about the Exocube on the manufacturer\u2019s website here: <a href=\"https:\/\/www.plymouthmedical.com\/exocube-prp-concentrate\">https:\/\/www.plymouthmedical.com\/exocube-prp-concentrate<\/a><\/p>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-mr9n75pq-19-a6d1dd7c4e624c23fd2d09c133abf7a4'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-3' data-fake-id='#toggle-id-3' class='toggler  av-title-above '  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-3' data-slide-speed=\"200\" data-title=\"How is this different from your competitors?\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: How is this different from your competitors?\" data-aria_expanded=\"Click to collapse: How is this different from your competitors?\">How is this different from your competitors?<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-3' aria-labelledby='toggle-toggle-id-3' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color '  itemprop=\"text\" ><p>Competitor clinics will typically concentrate platelets, but without purification or concentration of plasma. If concentration of plasma is offered, it is usually offered in a separate injection and for a significant extra cost. Our clinic offers the plasma concentrate and PRP together in one injection for one low cost.<\/p>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-mr9n75pq-18-195d275fae37c2fb56477f230f126903'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p id='toggle-toggle-id-4' data-fake-id='#toggle-id-4' class='toggler  av-title-above '  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-4' data-slide-speed=\"200\" data-title=\"What is the cost of the PRP injection at your clinic?\" data-title-open=\"\" data-aria_collapsed=\"Click to expand: What is the cost of the PRP injection at your clinic?\" data-aria_expanded=\"Click to collapse: What is the cost of the PRP injection at your clinic?\">What is the cost of the PRP injection at your clinic?<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-4' aria-labelledby='toggle-toggle-id-4' role='region' class='toggle_wrap  av-title-above'  ><div class='toggle_content invers-color '  itemprop=\"text\" ><p>We charge $1000 for the PRP, including the initial consultation with the physician and ultrasound-guided injection into the area of interest. Pricing on the mainland for this same procedure is typically $1500. Other allografts can be added, and complex injections of multiple areas can occur at additional costs. To schedule an initial consultation, you will be charged $150. This $150 is applied to the total treatment cost, should you decide to proceed with the treatment.<\/p>\n<\/div><\/div><\/div><\/section>\n<\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9n3pdk-b312f0c2ca44b3e8ff8b6f7f21c09c08\">\n#top .av-special-heading.av-mr9n3pdk-b312f0c2ca44b3e8ff8b6f7f21c09c08{\npadding-bottom:10px;\nfont-size:40px;\n}\nbody .av-special-heading.av-mr9n3pdk-b312f0c2ca44b3e8ff8b6f7f21c09c08 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr9n3pdk-b312f0c2ca44b3e8ff8b6f7f21c09c08 .av-special-heading-tag{\nfont-size:40px;\n}\n.av-special-heading.av-mr9n3pdk-b312f0c2ca44b3e8ff8b6f7f21c09c08 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr9n3pdk-b312f0c2ca44b3e8ff8b6f7f21c09c08 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr9n3pdk-b312f0c2ca44b3e8ff8b6f7f21c09c08 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr9n3pdk-b312f0c2ca44b3e8ff8b6f7f21c09c08 av-special-heading-h3 blockquote modern-quote  avia-builder-el-61  el_after_av_toggle_container  el_before_av_textblock  av-inherit-size'><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >References<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-mr9n42xv-7dbf962a9d1f6539bad92274fa2e4c39 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Costa, F. R., Purita, J., Martins, R., Pires, L., Mahmood, A., Santos, G. S., Kruel, A., Prot\u00e1sio Netto, J., &amp; Lana, J. F. (2026). Beyond Platelet Count: Rethinking Platelet-Rich Plasma Efficacy Through Growth Factor Biology and Functional Quality. Life, 16(2), 188. <\/span><a href=\"https:\/\/doi.org\/10.3390\/life16020188\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.3390\/life16020188<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Wang, S., Wei, X., Zhou, J., Zhang, J., Li, K., Chen, Q., Terek, R., Fleming, B. C., Goldring, M. B., Ehrlich, M. G., Zhang, G., &amp; Wei, L. (2014). Identification of \u03b12-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis. Arthritis &amp; rheumatology (Hoboken, N.J.), 66(7), 1843\u20131853. <\/span><a href=\"https:\/\/doi.org\/10.1002\/art.38576\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1002\/art.38576<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Showel, K. K., Evans, C. H., De la Vega, R. E., Hawse, G. P., Gonzalez Carta, K., Saris, D. B. F., Sellon, J. L., &amp; Boettcher, B. J. (2025). Preparation of alpha-2 macroglobulin\u2013rich plasma from human blood\u2014technique and compositional analysis of plasma, platelet-rich plasma, platelet-poor plasma, and alpha-2 macroglobulin\u2013rich plasma. Journal of Cartilage and Joint Preservation, 5(4), Article 100255. <\/span><a href=\"https:\/\/doi.org\/10.1016\/j.jcjp.2025.100255\"><span style=\"font-weight: 400;\">https:\/\/doi.org\/10.1016\/j.jcjp.2025.100255<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Profound properties of protein-rich, platelet-rich plasma matrices as novel, multi-purpose biological platforms in tissue repair, regeneration, and wound healing. Int J Mol Sci. 2024;25(14):7914. doi:10.3390\/ijms25147914<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vandooren J, Itoh Y. Alpha-2-macroglobulin in inflammation, immunity and infections. Front Immunol. 2021;12:803244. doi:10.3389\/fimmu.2021.803244<\/span><\/li>\n<\/ol>\n<\/div><\/section><\/p><\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":217,"menu_order":0,"template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-203","treatments","type-treatments","status-publish","format-standard","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Platelet Rich Plasma (PRP) Therapy - Hawaii Island Stem Cell Therapy and Regenerative Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ecommerceseo.us\/stemcellhawaii\/treatments\/platelet-rich-plasma-prp-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Platelet Rich Plasma (PRP) Therapy - 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