{"id":257,"date":"2026-06-30T20:29:06","date_gmt":"2026-06-30T20:29:06","guid":{"rendered":"https:\/\/ecommerceseo.us\/stemcellhawaii\/?post_type=treatments&#038;p=257"},"modified":"2026-07-06T20:21:54","modified_gmt":"2026-07-06T20:21:54","slug":"allogeneic-allograft","status":"publish","type":"treatments","link":"https:\/\/ecommerceseo.us\/stemcellhawaii\/treatments\/allogeneic-allograft\/","title":{"rendered":"Allogeneic Allograft"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1j50s0-84a257c0fc048a85efaf07b4782fa6c2\">\n.avia-section.av-1j50s0-84a257c0fc048a85efaf07b4782fa6c2{\nbackground-repeat:no-repeat;\nbackground-image:url(https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/allograft.webp);\nbackground-position:50% 50%;\nbackground-attachment:scroll;\n}\n.avia-section.av-1j50s0-84a257c0fc048a85efaf07b4782fa6c2 .av-section-color-overlay{\nopacity:0.4;\nbackground-color:#000000;\n}\n<\/style>\n<div 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.avia-button.av-g5jbc-97be3444d50461816fa231e5fc651944 .avia-svg-icon svg:first-child{\nfill:#ffffff;\nstroke:#ffffff;\n}\n#top #wrap_all .avia-button.av-g5jbc-97be3444d50461816fa231e5fc651944:hover .avia-svg-icon svg:first-child{\nfill:white;\nstroke:white;\n}\n<\/style>\n<a href='https:\/\/ecommerceseo.us\/stemcellhawaii\/contact\/'  class='avia-button av-g5jbc-97be3444d50461816fa231e5fc651944 avia-icon_select-no avia-size-large avia-color-light'   aria-label=\"Contact Us\"><span class='avia_iconbox_title' >Contact Us<\/span><span class='avia_button_background avia-button avia-color-theme-color-highlight' ><\/span><\/a>\n<\/div><\/p><\/div><div  class='flex_column av-9yr94-810d19b1096b26e2a90e3d3361a58a7b av_one_half  avia-builder-el-5  el_after_av_one_half  avia-builder-el-last  flex_column_div  '     ><\/div>\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div><div id='av_section_2'  class='avia-section av-mr0x1xmx-6df2d2ae14ee61ddd71af0769f736de6 main_color avia-section-large avia-no-border-styling  avia-builder-el-6  el_after_av_section  avia-builder-el-last  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-257'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column_table av-8qyv4-063e1ff20d494be19893208ec1d41b0d sc-av_one_half av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-8qyv4-063e1ff20d494be19893208ec1d41b0d\">\n.flex_column.av-8qyv4-063e1ff20d494be19893208ec1d41b0d{\nwidth:48%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-8qyv4-063e1ff20d494be19893208ec1d41b0d .av-flex-placeholder{\nwidth:4%;\n}\n<\/style>\n<div  class='flex_column av-8qyv4-063e1ff20d494be19893208ec1d41b0d av_one_half  avia-builder-el-7  el_before_av_one_half  avia-builder-el-first  mobile-text first flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr0x2ye6-6fe66e975440a9acf88b8922665cfddb\">\n#top .av_textblock_section.av-mr0x2ye6-6fe66e975440a9acf88b8922665cfddb .avia_textblock{\ncolor:#546673;\n}\n<\/style>\n<section  class='av_textblock_section av-mr0x2ye6-6fe66e975440a9acf88b8922665cfddb '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock av_inherit_color'  itemprop=\"text\" ><p>An allogeneic allograft is regenerative tissue donated from another individual that is applied to diseased or chronically injured tissues in the recipient.<\/p>\n<p>The FDA, under its regulation CFR 361, allows the use of donated human tissue in medicine without premarket review and approval, if the tissue is minimally manipulated, for homologous use, and does not purport to contain a cellular signaling function.<\/p>\n<p>The allogeneic allograft tissue we use at Hawaii Island Regenerative Medicine and Stem Cell Therapy exclusively meets guidelines for FDA exemption under CFR 361, since the donated tissue is designated as a structural support tissue, and is minimally manipulated prior to injection.<\/p>\n<p>A full description of the allogeneic allograft products used at Hawaii Island Regenerative Medicine and Stem Cell Therapy can be found here:\u00a0<a href=\"http:\/\/vittilabs.com\/\">vittilabs.com<\/a><\/p>\n<\/div><\/section><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-e1hq9-fd5e1d933c5611b809c36b8d7afdd8e0\">\n.flex_column.av-e1hq9-fd5e1d933c5611b809c36b8d7afdd8e0{\nwidth:48%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-e1hq9-fd5e1d933c5611b809c36b8d7afdd8e0 .av-flex-placeholder{\nwidth:4%;\n}\n<\/style>\n<div  class='flex_column av-e1hq9-fd5e1d933c5611b809c36b8d7afdd8e0 av_one_half  avia-builder-el-9  el_after_av_one_half  el_before_av_one_full  mobile-text flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9o1j48-a91af04d5bee226aba8381483e62c223\">\n.avia-image-container.av-mr9o1j48-a91af04d5bee226aba8381483e62c223 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr9o1j48-a91af04d5bee226aba8381483e62c223 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr9o1j48-a91af04d5bee226aba8381483e62c223 av-styling- avia-align-center  avia-builder-el-10  avia-builder-el-no-sibling  imageshadow'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-324 avia-img-lazy-loading-not-324 avia_image ' src=\"https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/allogeneic-allograft-treatment.webp\" alt='Allogeneic allograft regenerative tissue injection therapy' title='allogeneic-allograft-treatment'  height=\"437\" width=\"580\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/allogeneic-allograft-treatment.webp 580w, https:\/\/ecommerceseo.us\/stemcellhawaii\/wp-content\/uploads\/2026\/06\/allogeneic-allograft-treatment-300x226.webp 300w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/div><\/div><\/div><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><div  class='flex_column av-14lm9-b20e22e543cdd8106689a15711944508 av_one_full  avia-builder-el-11  el_after_av_one_half  avia-builder-el-last  mobile-text first flex_column_div av-animated-generic bottom-to-top  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9nvwzz-a0fe80191809408467153c47c7e7e7ce\">\n#top .av_textblock_section.av-mr9nvwzz-a0fe80191809408467153c47c7e7e7ce .avia_textblock{\ncolor:#546673;\n}\n<\/style>\n<section  class='av_textblock_section av-mr9nvwzz-a0fe80191809408467153c47c7e7e7ce '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock av_inherit_color'  itemprop=\"text\" ><p>In our clinic these products are frequently combined with allograft products, or PRP, (link here or allograft page and PRP page)so that full cell signaling function can be preserved.<\/p>\n<p>The allogeneic allograft tissue that we use at Hawaii Island Stem Cell and Regenerative Medicine is sourced from umbilical cord donated during live and healthy C section birth occurring only int her United States. All of our products come from a lab that is FDA registered and CGMP certified. In this process, all donors are screened according to accredited Human Tissue Bank standards, and additionally are screened to rule out any infections diseases, inculding COVID vaccination.<\/p>\n<p>In both the laboratory and in small scale clinical trials to date, these products have been shown to be uniquely helpful in regeneration of chronically diseased tissues. These birth products are a purified portion of the umbilical cord, also known as the Whartons Jelly, and although not intended to provide signaling effects due to FDA regulations, and while no claims can be made as to live cell activity, these products are generally thought to contain live Mesenchymal Stem Cells (MSC\u2019s) live Exosomes (Extracellular Signaling Vesicles) and Polypeptide Enriched Matrix (PEM).1<\/p>\n<p>MSC\u2019s are thought to exert their effects through paracrine signaling, that is, the release of signaling factors to communicate with the surrounding cells and cellular environment in favor of regeneration and repair. In large part, they mediate this signaling effect through exosomes, which are small spherical membrane structures that are released from mesenchymal stem cells to circulate in the extracellular space. These spherical membranes are packages containing signaling material, protein, and mRNA, which can turn on genes and genomic proteins of growth and repair in the target tissue, and modulate the immune response in order to reduce inflammation. And finally, the polypeptide enriched matrix (PEM) (extracellular) component of the Whartons jelly, contains the growth media and structural support for the entire system, containing growth factors, peptides, and hyaluronic acid, to name a few.<\/p>\n<p>Although, due to current regulations we cannot make any claims regarding the effectiveness of these treatments, we encourage you to schedule an initial consultation (include link) with the physician to discuss these options, and to discuss, in the physicians professional opinion, how these treatments may benefit you.<\/p>\n<p>A short list of the conditions we treat at Hawaii Island Stem Cell Therapy and Regenerative Medicine includes:<\/p>\n<ul>\n<li>chronic myofascial pain<\/li>\n<li>back pain<\/li>\n<li>osteoarthritis<\/li>\n<li>sports injury<\/li>\n<li>Chronic tendonitis<\/li>\n<li>Chronic Ligament pain, inflammation and laxity<\/li>\n<li>Rotator cuff injury<\/li>\n<li>Knee arthritis and meniscal tears<\/li>\n<li>Plantar fasciitis<\/li>\n<li>Ankle: arthritis and chronic sprains<\/li>\n<li>carpal tunnel<\/li>\n<li>Hip pain: chronic strain or osteoarthritis<\/li>\n<\/ul>\n<p>Please contact us or schedule an appointment to see if regenerative musculoskeletal medicine at Hawaii Island Stem Cell Therapy and Regenerative Medicine is right for you.<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr9nwkza-2dad9f3e27c9c32a39527e7b5c1e7db3\">\n#top .av-special-heading.av-mr9nwkza-2dad9f3e27c9c32a39527e7b5c1e7db3{\npadding-bottom:10px;\nfont-size:26px;\n}\nbody .av-special-heading.av-mr9nwkza-2dad9f3e27c9c32a39527e7b5c1e7db3 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-mr9nwkza-2dad9f3e27c9c32a39527e7b5c1e7db3 .av-special-heading-tag{\nfont-size:26px;\n}\n.av-special-heading.av-mr9nwkza-2dad9f3e27c9c32a39527e7b5c1e7db3 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-mr9nwkza-2dad9f3e27c9c32a39527e7b5c1e7db3 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-mr9nwkza-2dad9f3e27c9c32a39527e7b5c1e7db3 .av-special-heading-tag{\nfont-size:0.8em;\n}\n}\n<\/style>\n<div  class='av-special-heading av-mr9nwkza-2dad9f3e27c9c32a39527e7b5c1e7db3 av-special-heading-h3 blockquote modern-quote  avia-builder-el-13  el_after_av_textblock  el_before_av_textblock  av-inherit-size'><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >References<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-mr9nwwt9-cec3cc9145ccf3c8784fd827274e3944 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><ol>\n<li>AH Amol H Trivedi, et al. &#8220;The Categorization of Perinatal Derivatives for Orthopedic Applications.&#8221; Biomedicines, 2024.<\/li>\n<\/ol>\n<\/div><\/section><\/p><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":258,"menu_order":0,"template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-257","treatments","type-treatments","status-publish","format-standard","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - 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