Ozone is a natural medical therapy that works through the creation of oxygenated signaling molecules and metabolic molecules, resulting in upregulation of metabolism and modulation of key regulatory processes in the body. For a full discussion of ozone in medicine, see our discussion on the www.vitalitymedicine.org page.

At the Hawaii Island Center for Regenerative Medicine, the basic prolotherapy mixture is usually accompanied by an injection of ozone gas in a technique called Prolozone, which was termed by Dr. Frank Shallenberger, MD, HMD, ABAAM. Dr. Lawinski received formal Prolozone training with Frank Schallenberger in 2013. Over the years, Dr. Schallenberger and hundreds of other ozone doctors have found that the use of ozone in the proliferant mixture causes the joints and ligaments to heal more rapidly than in traditional prolotherapy.

We theorize that ozone combines with signaling molecules in the body, enhancing those signaling molecules’ ability to control growth and repair. Ozonated signaling molecules also act as regulators of the immune system, resulting in less inflammation within chronically inflamed areas. The results are consistently better healing of damaged tissue, with increased function and reduction of pain.

Over the years, a variety of proliferants have been used. The most common, safe, and inexpensive proliferant—and the one we use at the Hawaii Island Center for Regenerative Medicine—is a high-concentration dextrose (sugar water) solution. A variety of vitamins and nutrients are added to the dextrose solution to increase efficacy. The presence of the solution in the affected musculoskeletal area causes mild, controlled irritation to the targeted tissue, which eventually leads to increased blood flow, improved nutrient delivery, and upregulation of the body’s natural healing response.